產品詳細信息: 產品編號 Rs-2890R 英文名稱 Anti-HDAC7 中文名稱 組蛋白去乙?;?抗體 抗體介紹:HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription. 別 名 HD 7a; HD7a; HDAC 7; HDAC 7A; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A; DKFZP586J0917. 產品類型 一抗 乙?;贵w 抗體來源 Rabbit 克隆號 Polyclonal 交叉反應 hu, rat, mo 蛋白分子量 Predicted Molecular Weight: 31kDa 性狀 Lyophilized or Liquid 濃度 1mg/1ml 免疫原 KLH conjugated synthetic peptide derived from human HDAC7 亞型 IgG 純化方法 affinity purified by Protein A 儲存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 產品應用 WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100 (石蠟切片需做抗原修復)Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. 研究領域 腫瘤 免疫學 信號轉導 細胞凋亡 轉錄調節因子 保存 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 公司提供的.已被國內外廣大科研工作者使用,廣泛用于分子生物學、免疫學等試驗中。