產品詳細信息: 產品編號 Rs-2895R 英文名稱 Anti-HDAC12 中文名稱 組蛋白去乙?;?2抗體 抗體介紹:Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. 別 名 HD 1; HD1; HDAC 1; hdac1: histone deacetylase 1; Histone deacetylase 1 (HD1); Histone deacetylase 1; RPD3 (reduced potassium dependency yeast homolog) like 1; RPD3 (reduced potassium dependency); RPD3; RPD3L1; DKFZp686H12203; GON 10. 產品類型 一抗 乙?;贵w 抗體來源 Rabbit 克隆號 Polyclonal 交叉反應 hu, rat, mo 蛋白分子量 Predicted Molecular Weight: 65kDa 性狀 Lyophilized or Liquid 濃度 1mg/1ml 免疫原 KLH conjugated synthetic peptide derived from human HDAC12 亞型 IgG 純化方法 affinity purified by Protein A 儲存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 產品應用 WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100 (石蠟切片需做抗原修復)Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. 研究領域 腫瘤 免疫學 信號轉導 細胞凋亡 轉錄調節因子 保存 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
公司提供的.已被國內外廣大科研工作者使用,廣泛用于分子生物學、免疫學等試驗中。
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