Description: Anti ALK(R1275Q) Mouse Monoclonal Antibody
Background: Anaplastic lymphoma kinase (ALK) also known as CD246 (cluster of differentiation 246) is a tyrosine kinase receptor that plays an important role in the development of the brain and nervous systems. Deficiencies in ALK, which most commonly as a fusion with other genes, are indicated in cancers.
Immunogen: A synthetic peptide from the internal region of ALK which includes the mutation of R1275Q, human origin.
Species Reactivity: Recognizes ALK(R1275Q), but not wild type ALK protein from vertebrates.
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles
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Western blot:
Western blot analysis of recombinant ALK(R1275Q) and wildtype proteins. Purified His-tagged ALK(R1275Q) protein (amino acids 1060-1620, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti ALK(R1275Q) mouse monoclonal antibody (Cat. #26151).