Background: BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene. It binds to oncogene BCL2, by which enhances the anti apoptotic effects of BCL2 and represents a link between growth factor receptors and anti apoptotic mechanisms. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.
Immunogen: A synthetic peptide from the central region of Bag1 protein, human origin.
Species Reactivity: Anti Bag1 rabbit polyclonal antibody recognizes Bag1 from vertebrates.
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
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Western blot:
Western blot analysis of recombinant Bag1 protein. Purified full length His-tagged Bag1 protein was blotted with anti Bag1 rabbit polyclonal antibody (Cat. #21231).