Description
Analysis Note Another commonly used unit of activity is the KIU （Kallikrein Inhibitor Unit）.
1 TIU ∼ 1,300 KIU.
Biochem/physiol Actions Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or <3. Effective concentration equimolar with protease.
General description Aprotinin is a protein consisting of 58 amino acids, arranged in a single polypeptide chain that is crosslinked by three disulfide bridges.
Unit Definition 1 U corresponds to 1 biological kallikrein inhibitor unit （KIU）
Properties
assay ~80% （HPCE）
form crystalline （fine）
quality lyophilized
mol wt mol wt ~6,500
color white
storage temp. 2-8°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements 22
WGK Germany 1
RTECS YN5080000
References
reference Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182, 83-89, （1990）
Dignam, J.D., Preparation of extracts from higher eukaryotes. Meth. Enzymol. 182, 194-203, （1990）
, Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach, （1989）, 247
Trautschold, I., et al. Biochem. Pharmacol. 16, 59, （1967）
Gebhard, W., Review: Biochemistry of aprotinin and aprotinin-like inhibitors. Res. Monogr. Cell Tissue Physiol. 12, 375, （1986）
Merck Merck 13,761
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蛋白酶抑制劑 基本信息
中文名稱: 蛋白酶抑制劑
中文同義詞: 蛋白酶抑制劑
英文名稱: 1 VIAL PROTEASE-INHIBITOR-MIX G （31,2 MG）
英文同義詞: 1 VIAL PROTEASE-INHIBITOR-MIX G （31,2 MG）
CAS號:
分子式:
分子量: 0
EINECS號:
相關類別:
Mol文件: Mol File
