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英文名稱 Anti-14-3-3 Tau/FITC
中文名稱 FITC標記的14-3-3τ蛋白抗體
別 名 14 3 3 protein T cell; 14 3 3 protein tau; 14 3 3 protein theta; 14 3 3 tau; 14 3 3 theta; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 1433T_HUMAN; 1C5; HS1; KCIP1; Protein HS1; Protein kinase C inhibitor protein 1; Protein tau; tyr3/trp5 monooxygenase activation protein, theta; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide; YWHAQ.  
說 明 書 100ug  
研究領域 細胞生物  信號轉導  干細胞  細胞凋亡  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human 14-3-3 Tau
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
FITC標記的14-3-3τ蛋白抗體保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FITC標記的14-3-3τ蛋白抗體產品介紹 background:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.

Subcellular Location:
Cytoplasm. In neurons, axonally transported to the nerve terminals.

Tissue Specificity:
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.

Post-translational modifications:
Ser-232 is probably phosphorylated by CK1.

Similarity:
Belongs to the 14-3-3 family.

Database links:

Entrez Gene: 10971 Human

Entrez Gene: 768311 Cow

Entrez Gene: 22630 Mouse

Entrez Gene: 25577 Rat

Omim: 609009 Human

SwissProt: Q3SZI4 Cow

SwissProt: P27348 Human

SwissProt: P68254 Mouse

SwissProt: P68255 Rat

Unigene: 74405 Human

Unigene: 289630 Mouse

Unigene: 2502 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.