FITC標記的α2巨球蛋白樣蛋白1抗體α2ML1是我司為您提供的高品質抗體，公司生產的每一個抗體都經過嚴格檢測和穩定性測試，保證了結果的準確性、敏感性、特異性。公司產品質量有保證，*且我司擁有完善的市場營銷體系、現代化管理體系和專業化物流配送系統，zui大程度滿足國內外生命科研人員的產品需求，公司現經營抗體、ELISA試劑盒、標準品、染色液、染色試劑盒、培養基等多種科研產品，歡迎前來選購！
英文名稱 Anti-A2ML1/FITC
中文名稱 FITC標記的α2巨球蛋白樣蛋白1抗體α2ML1
別 名 A2ML 1; Alpha 2 macroglobulin like 1; Alpha 2 macroglobulin like protein 1; C3 and PZP like alpha 2 macroglobulin domain containing protein 9; CPAMD9; DKFZp686C1729; DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010; FLJ16045; FLJ25179; FLJ39129; FLJ41597; FLJ41598; FLJ41607; A2ML1_HUMAN.  
說 明 書 100ug  
研究領域 細胞生物  免疫學  神經生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Horse, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 159kDa
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human A2ML1
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
FITC標記的α2巨球蛋白樣蛋白1抗體α2ML1保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FITC標記的α2巨球蛋白樣蛋白1抗體α2ML1產品介紹 background:
alpha-2-Macroglobulin (alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, alpha-2M was characterized as a pan-proteinase inhibitor that was able to “bait” proteinases into cleaving specific peptide sequences on alpha-2M. This interaction induces a conformational change in alpha-2M, thus enabling it to “trap” the proteinase and further inhibit its activity. Subsequently, alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGF beta) in serum is primarily bound to alpha-2M, which renders TGF∫ inactive. Mutations and deletions in the gene encoding alpha-2M are associated with an increased incidence of Alzheimer's Disease (AD). Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is expressed in the epidermis and may play a role in keratinocyte differentiation.

Function:
A2ML1 is a new member of the alpha 2-macroglobulin protease inhibitor family, and shares most the characteristics of this family. It is the first family member detected in the epidermis and may play an important role during desquamation by inhibiting extracellular proteases. The alpha-macroglobulin (AM) superfamily of proteins contains both complement components and protease inhibitors, including A2M and A2ML1. AM proteins display a unique trap mechanism of inhibition, by which the AM inhibitor undergoes a major conformational change upon its cleavage by a protease, thus trapping the protease and blocking it from subsequent substrate binding.

Subunit:
Monomer.

Subcellular Location:
Secreted

Tissue Specificity:
In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.

Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

Database links:

Entrez Gene: 144568 Human

Omim: 610627 Human

SwissProt: A8K2U0 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.